0.2306
7667766266
x

DENND1B Gene

iasparliament Logo
March 18, 2025

Why in the News?

Recent research by the University of Cambridge has identified the DENND1B gene as a significant contributor to obesity in Labrador Retrievers and humans.

  • DENND1B – An obesity gene in dogs and humans.
  • The DENND1B gene is also found in humans, in whom it was also associated with higher body mass.
  • 5 obesity-associated genes – The researchers identified five obesity-associated genes, and then checked if these genes were also relevant to human obesity.
  • Among the 5 obesity-associated genes, DENND1B gene was found to be most strongly associated with body mass and obesity in labradors.
  • Regulates appetite – The gene essentially interferes with a brain signalling pathway that helps regulate our appetite.
  • Weight gain – This gene affects the body's hunger and energy balance, which can lead to weight gain.
  • Dogs with a mutation in this gene had about 8% more body fat than those without it.
  • Multifaceted interplay – Obesity is a complex condition resulting from a multifaceted interplay between genetic predispositions and environmental factors like diet and lifestyle, rather than being solely determined by either.

References

The Indian express | DENND1B Gene

Login or Register to Post Comments
There are no reviews yet. Be the first one to review.

ARCHIVES

MONTH/YEARWISE ARCHIVES

sidetext
Free UPSC Interview Guidance Programme
sidetext