20/06/2020 - S & T

KEY POINTS

·         Dexamethasone is an anti-inflammatory drug, commonly used to treat conditions in which the body’s immune system does not function properly, and causes inflammation and tissue damage.

·         It reduces the production of the chemicals that cause inflammation and also reduces the activity of the immune system by affecting the way white blood cells function.

·         Dexamethasone falls in a category called corticosteroids, which closely mimic cortisol, the hormone naturally produced by the adrenal glands in humans. It is commonly used in treatment for rheumatological inflammatory conditions: inflammations of muscles, inflammation of blood vessels, chronic arthritis, and lupus.

·         During the SARS outbreak in 2003, corticosteroid therapy was used to reduce inflammatory-induced lung injury. In Covid-19, too, many countries are investigating the effectiveness of corticosteroid therapy on patients with an acute respiratory infection.

·         The trials found no evidence of benefit for patients who did not require oxygen, survival benefit is clear and large only in patients who are sick enough to require oxygen treatment.

·         Also, the trial did not study patients outside the hospital setting. Therefore, the drug is not recommended to the large population of mild patients.

·         The Health Ministry protocol says a larger dose of glucocorticoid will delay the removal of coronavirus due to immunosuppressive effects.

Sir pls review

Sir good afternoon

Pls review

please review

Please review